Ingredients
POLYNUCLEOTIDES (PN)
THE DOUBLE HELICAL KEY TO UNLOCKING THE SKIN’S SECRET
PURE EXTRACTION
Extracted from French wild salmon from a state-of-the-art facility in Brittany, France, our process produces pure, long-chain, double-helical PN that provide long-lasting tissue regeneration2.
NATURAL REGENERATION
Biocompatible and non-immunogenic, PN stimulate the skin tissue’s reparative processes to improve skin tone, repair scarring, and restore skin barrier function3.
WOUND HEALING
PN stimulate the migration and proliferation of fibroblast cells, promoting wound healing and the remodelling of scar tissue4; visibly diminishing scar appearance, and even skin tone and texture.
ANTI-INFLAMMATORY
PN suppress pro-inflammatory cytokines such as TNF-α,IL-1β, and IL-6 (p<0.05), but stimulate expression of VEGF,5 reducing skin redness and irritation, increasing skin healing, and restoring skin barrier function.
References: 1. Juncan, A. M., Moisă, D. G., Santini, A., Morgovan, C., Rus, L. L., Vonica-Țincu, A. L., & Loghin, F. (2021). Advantages of hyaluronic acid and its combination with other bioactive ingredients in cosmeceuticals. Molecules, 26(15), 4429. 2. Data on File. 3. Pitassi, L. H. U., Pearson, K., de Assis, L. A., Biesman, B., Calomeni, M., Bay-Aguilera, S., & Wyles, S. P. (2024). Polynucleotides in Skin Regeneration: Targeting the Adenosine A2A Receptor and Salvage Pathway. Dermatologic Surgery, 50(11S), S131-S134. 4. Kim, J. H., Kwon, T.-R., Lee, S. E., Jang, Y. N., Han, H. S., Mun, S. K., & Kim, B. J. (2020). Comparative Evaluation of the Effectiveness of Novel Hyaluronic Acid-Polynucleotide Complex Dermal Filler. Scientific Reports, 10(1), 5127. https://doi.org/10.1038/s41598-020-61952-w 5. Han, J., Jung, J., Hwang, L., Ko, I., Nam, O., Kim, M., Lee, J., Choi, B., & Lee, D. (2018). Anti‑inflammatory effect of polydeoxyribonucleotide on zoledronic acid‑pretreated and lipopolysaccharide‑stimulated RAW 264.7 cells. Experimental and Therapeutic Medicine. https://doi.org/10.3892/ etm.2018.6186
HYALURONIC ACID
THE UNRIVALLED HYDRATOR - A PILLAR OF SKIN SCIENCE
COLLAGEN SYNTHESIS
Fully biocompatible, hyaluronic acid also stimulates the production of collagen, increasing the skin’s elasticity and reducing wrinkle formation.
SKIN HYDRATION
A natural humectant, hyaluronic acid (HA) acts as a primary moisturizing component in the extracellular matrix, hydrating the skin and forming its moisture barrier1.
AMINO ACID COMPLEX
THE BUILDING BLOCKS OF HEALTHY SKIN, PRECISELY FORMULATED
BENEFITS OF
INCLUDED AMINO ACIDS
BENEFITS OF
INCLUDED AMINO ACIDS
DRY SKIN
Dry skin has insufficient NMF. The cells of the stratum corneum are loosely arranged
MOIST SKIN
Moist skin has a good balance of NMF and epidermal lipids. The cells of the stratum corneum are tightly arranged.
VITAMIN B COMPLEX
ESSENTIAL VITAMINS – THE CATALYSTS THAT RECHARGES SKIN ENERGY
BENEFITS OF
5 INCLUDED VITAMINS
Impact of B vitamins on human fibroblast proliferation after 24, 48, and 72 hours of treatment.
According to Rembe et al. (2018), B vitamins (both individually and in combination) promote human fibroblast proliferation, thus increasing collagen production and providing anti-aging effects12.
References: 1. Miyamoto, K. , Munakata, Y. , Fujii, K. , Summer, W. , Yang, L. , Sudarsana, S. and Furue, M. (2024) Six Amino Acids among Natural Moisturizing Factors Responsible for Skin Hydration: Improvement and Anti-Aging of Skin by Galactomyces Ferment Filtrate-PiteraTM Containing Skin Moisturizer. Journal of Cosmetics, Dermatological Sciences and Applications, 14, 113-127. doi: 10.4236/jcdsa.2024.142008. 2. Kwon, K. C., Won, J. G., Seo, J. H., Kwon, O. S., Kim, E. H., Kim, M. S., & Park, S. W. (2022). Effects of arginine glutamate (RE:pair) on wound healing and skin elasticity improvement after CO2 laser irradiation. Journal of cosmetic dermatology, 21(10), 5037–5048. https://doi.org/10.1111/jocd.14957 3. Fowler, J. (2012). Understanding the role of natural moisturizing factor in skin hydration. Pract. Dermatol, 9, 36-40. 4. Nomoto, Tatsuya MD; Iizaka, Shinji PhD, RN, PHN. Effect of an Oral Nutrition Supplement Containing Collagen Peptides on Stratum Corneum Hydration and Skin Elasticity in Hospitalized Older Adults: A Multicenter Open-label Randomized Controlled Study. Advances in Skin & Wound Care 33(4):p 186-191, April 2020. | DOI: 10.1097/01.ASW.0000655492.40898.55 5. Moro, J., Tom., D., Schmidely, P., Demersay, T. C., & Azzout-Marniche, D. (2020). Histidine: A Systematic Review on Metabolism and Physiological Effects in Human and Different Animal Species. Nutrients, 12(5), 1414. https://doi.org/10.3390/nu12051414 6. Carvalho, B. G., Raniero, L. J., Martin, A. A., & Favero, P. P. (2013). Phenylalanine ab initio models for the simulation of skin natural moisturizing factor. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 106, 73–79. https://doi.org/10.1016/j.saa.2012.12.082 7. Sewon Kang, Jin Ho Chung, Joo Heung Lee, Gary J. Fisher, Yian Sheng Wan, Elizabeth A. Duell, John J. Voorhees,Topical N-Acetyl Cysteine and Genistein Prevent Ultraviolet-Light-Induced Signaling That Leads to Photoaging in Human Skin in vivo, Journal of Investigative Dermatology, Volume 120, Issue 5, 2003, Pages 835-841, ISSN 0022-202X, https://doi.org/10.1046/j.1523-1747.2003.12122.x. 8. Peng-Fei Wu, Li-Hong Long, Jian-Hua Zeng, Xin-Lei Guan, Jun Zhou, You Jin, Lan Ni, Fang Wang, Jian-Guo Chen, Na Xie, Protection of l-methionine against H2O2-induced oxidative damage in mitochondria, Food and Chemical Toxicology, Volume 50, Issue 8, 2012,Pages 2729-2735, ISSN 0278-6915, https://doi.org/10.1016/j.fct.2012.04.047. 9. Slominski, A., Zmijewski, M. A., & Pawelek, J. (2012). L-tyrosine and L-dihydroxyphenylalanine as hormone-like regulators of melanocyte functions. Pigment cell & melanoma research, 25(1), 14–27. https://doi.org/10.1111/j.1755-148X.2011.00898.x 10. Yoshimura, T., Manabe, C., Nagumo, J., Nagahama, T., Sato, T., & Murakami, S. (2023). Taurine accelerates the synthesis of ceramides and hyaluronic acid in cultured epidermis and dermal fibroblasts. Experimental and Therapeutic Medicine, 26, 512. https://doi.org/10.3892/etm.2023.12211 11. Maarouf, M., Vaughn, A. R., & Shi, V. Y. (2018). Topical micronutrients in atopic dermatitis—An evidence‐based review. Dermatologic therapy, 31(5), e12659. 12. Rembe, J. D., Fromm-Dornieden, C., & Stuermer, E. K. (2018). Effects of Vitamin B Complex and Vitamin C on Human Skin Cells: Is the Perceived Effect Measurable?. Advances in skin & wound care, 31(5), 225–233. https://doi.org/10.1097/01.ASW.0000531351.85866.d9 13. Kimball AB, Kaczvinsky JR, Li J, et al. Reduction in the appearance of facial hyperpigmentation after use of moisturizers with a combination of topical niacinamide and N-acetyl glucosamine: results of a randomized, double-blind, vehicle-controlled trial. Br J Dermatol 2010;162:435-41. 14. Proksch, E., & Nissen, H. P. (2002). Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation. The Journal of dermatological treatment, 13(4), 173–178. https://doi.org/10.1080/09546630212345674 15. Fujishiro, M., Yahagi, S., Takemi, S. et al. Pyridoxine stimulates filaggrin production in human epidermal keratinocytes. Mol Biol Rep 48, 5513–5518 (2021). https://doi.org/10.1007/s11033-021-06563-y 16. Debowska, R., Rogiewicz, K., Iwanenko, T., Kruszewski, M., & Eris, I. (2005). Folic acid (folacin)-New application of a cosmetic ingredient. Kosmetische Medizin, 26(3), 123.
PEPTIDE COMPLEX
MULTI-TARGET SKIN REVIVAL – NEXT-GEN PEPTIDE TECHNOLOGY
WRINKLE REDUCTION
Acetyl Hexapeptide-8 was demonstrated to reduce wrinkle depth and roughness by 27% (p<0.075) after 30 days of twice a day topical application in volunteers (n=10)1.
ANTI-OXIDATION
Caffeoyl sh-Decapeptide-9 demonstrates strong anti-oxidation effects, scavenging 90% of free radicals in a DPPH assay, reducing cell damage through aging and UV3.
COLLAGEN FORMATION
Copper Tripeptide-3 significantly increased fibroblast formation compared with controls by more than 2-fold (p<0.001) in human cell lines,2 promoting collagen formation.
BARRIER RESTORATION
SKIN BRIGHTENING
Nicotinoyl Tripeptide-1 reduced melanin production in stimulated melanocytes by 20% compared with niacinamide (vitamin B3) in cell assays3.
ANTI-INFLAMMATORY
Caffeoyl sh-Decapeptide-9 significantly improved (p<0.001) eczema in a clinical trial of 21 patients; halving the SCORing Atopic Dermatitis (SCORAD) value after 4 weeks3.
SKIN QUALITY IMPROVEMENT
References: 1. Blanes-Mira, C., Clemente, J., Jodas, G., Gil, A., Fern.ndez-Ballester, G., Ponsati, B., Gutierrez, L., P.rez-Pay., E., & Ferrer-Montiel, A. (2002). A synthetic hexapeptide (Argireline) with antiwrinkle activity. International journal of cosmetic science, 24(5), 303–310. https:// doi.org/10.1046/j.1467-2494.2002.00153.x 2. Pollard, J. D., Quan, S., Kang, T., & Koch, R. J. (2005). Effects of copper tripeptide on the growth and expression of growth factors by normal and irradiated fibroblasts. Archives of facial plastic surgery, 7(1), 27–31. https://doi.org/10.1001/ archfaci.7.1.27 3. Data on File
SKIN HYDRATION
A natural humectant, hyaluronic acid (HA) acts as a primary moisturizing component in the extracellular matrix, hydrating the skin and forming its moisture barrier.HA has also been shown to beneficially regulate the inflammatory response and promote wound healing by providing signalling and structural support.1
References:
1. Litwiniuk, M., Krejner, A., Speyrer, M. S., Gauto, A. R., & Grzela, T. (2016). Hyaluronic Acid in Inflammation and Tissue Regeneration. Wounds : a compendium of clinical research and practice, 28(3), 78–88.
COLLAGEN SYNTHESIS
Nuvogen Symphony’s hyaluronic acid is fully biocompatible and is derived from non-animal origin that closely resemble the natural hyaluronic acid in our skin, thus reducing the risk of allergic reactions. HA also stimulates the production of collagen, increasing the skin’s elasticity and reducing wrinkle formation